Liver lesion(s)

Referrers should use this page when referring patients to public adult hepatology outpatient services for liver lesions.
Emergency referral
If any of the following are present or suspected, refer the patient to the emergency department or seek emergency medical advice if in a remote region.
  • Liver lesion(s) with evidence of active haemorrhage
  • Associated with liver decompensation (e.g. jaundice, ascites, encephalopathy, variceal bleeding)
Immediate referral
Orange exclamation mark in triangle: orange alertImmediately contact on-call registrar or service to arrange immediate ophthalmology assessment (seen within 7 days):
  • Liver lesion(s) on imaging suggestive of primary liver cancer (hepatocellular carcinoma (HCC) or cholangiocarcinoma)
  • Symptomatic liver lesion(s)
  • Rapidly enlarging liver lesion(s)
  • Vascular invasion

To contact the relevant service, see Clinician Assist WA: Acute Gastroenterology assessment (external site)

Clinical indications for outpatient referral
If any of these issues are present, refer to outpatient services through the Central Referral Service (CRS).
  •  Liver lesion(s) as seen on imaging
Mandatory information
Referrals missing 'mandatory information' with no explanation provided may not be accepted by site. If 'mandatory information' is not included, the explanation must be provided in the body of the referral (e.g. patient unable to access test in regional or remote areas or due to financial reason).

This information is required to inform accurate and timely triage. If unable to attach reports, please include relevant information/findings in the body of the referral and advise where (provider) investigation/imaging was completed.

History
  • Relevant history, onset, duration, and severity of symptoms
  • History of liver disease and/or previous cancer(s)
  • History of diabetes
  • Current medication list
  • Any known allergies
Examination
  • Height and weight, or BMI
Investigations
  • FBC
  • LFT
  • Ultrasound (US) or MRI or CT of the abdomen
Highly desirable
History
  • Family history of hepatocellular carcinoma (HCC)/cholangiocarcinoma
  • Alcohol and illicit drug history
  • Evidence of liver fibrosis/ cirrhosis
Examination
  • Nil
Investigations
  • INR
  • Alpha fetoprotein (AFP)
  • HBV and HCV serology
  • Other tumour markers - CA 19/9, CEA
  • Multiphase MRI liver with contrast OR Multiphase CT liver with contrast (for solid liver lesion > 1cm)
Indicative clinical urgency category

Category 1

Appointment within 30 days

  • Known chronic liver disease with:
    • Liver lesion suggestive of primary liver cancer according to radiology report
    • Raised alpha fetoprotein (AFP)

Category 2

Appointment within 90 days

  • Liver lesion(s) on imaging suggestive of benign liver lesion(s) requiring further characterisation

Category 3

Appointment within 365 days

  • No defined category 3 criteria
Exclusions
  • Haemangioma or focal nodular hyperplasia previously documented by either MRI or 2 forms of imaging
  • Small (< 2cm) stable incidental haemangioma confirmed on 2 ultrasounds (US), 3 to 6 months apart, with no risk factors for liver disease
  • For a solid liver lesion < 1cm, a repeat targeted US in 3 months before referring to outpatient services is required
  • Reported simple liver cysts on imaging
  • Gall bladder polyps
    • Refer to general surgery
Useful information
  • Nil

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Last reviewed: 29-04-2025