Investigation of functional implications of a schizophrenia associated non-synonymous nucleotide exchange in the gene for the Phosphatidylinositol, 5 kinase 2alpha (PIP5K2A) gene

These studies aim at investigation of a possible impact of this SNP, which alters asparagine to serine, on mRNA expression, mRNA processing (splicing), protein expression and enzyme function.

To study enzyme function, we are currently   preparing a recombinant protein containing either one of the variants. These will be used for enzyme activity assay by determining phosphorylation levels.

This project is supported by NHMRC Project Grant 404012.

Contact

Researchers Professor Dieter Wildenauer or Dr Sibylle Schwab